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LYMPHOMA INDUCED STUDIES

INTRODUCTION

Combating cancer is of paramount importance today. Multidisciplinary scientific investigations are making the best efforts to combat this disease, but the sure-shot, perfect cure is yet to be brought into world medicine. An alternative solution to western medicine embodied with severe side effects, is the use of medicinal plant preparations to arrest the insidious nature of the disease. Of the 92 anticancer drugs commericially available, prior to 1983 in the United States, approved worldwide between 1983 and 1994, approximately 62% can be related to natural origins . Many herbs have been evaluated in clinical studies and are currently being investigated phytochemicaly to understand their tumoricidal actions against various cancers. The rich and diverse plant sources of India are likely to provide effective anticancer agents. One of the best approaches in the search for anticancer agents from plant resources is the selection of plants based on ethanomedical leads.

Hence, in the present study, based on the ethanomedical claims, the antitumor properties of the methanolic extract of Morinda citrifolia against Dalton’s lymphoma ascites (DLA) - induced tumor inoculation was evaluated along with determining its antioxidant status.


MATERIALS AND METHODS

Extraction

The fruits was shade dried, powdered and extracted (20 g) with MeOH using a Soxhlet extractor for 18 – 20 h. The extract was concentrated and dried under reduced pressure and controlled temperature (40ºC – 50ºC) in a rotary evaporator. The extract yielded a reddish brown crystalline solid weighing 2 g and was preserved in a refrigerator at 4ºC until further use.

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