this is a fantastic ebook and highly recommended.
naturally you have to take the stuff about rejecting amazon exclusivity with a pinch of salt - some moral hazard there..
my only problem is that I read this, got all excited about Smashwords, tried to publish something (i had been exclusive to amazon before then), and found that Smashwords is utterly terrible. I tried about 10 times to publish a single book and the system would keep rejecting it. Their idea of 'help' or 'support' was providing no specific solution, just pointing me towards FAQs and the Style Guide.
So, in short, read this book for its helpful general advice and good motivational info, avoid Smashwords.