Pellets an Extended Release Dosage Form
Pellets are the multiparticulate drug delivery systems, prepared by various pelletization techniques. Pelletization is referred to as an agglomeration process, that converts fine powders or granules of bulk drugs or excipients into small, free flowing, spherical or semi-spherical units, referred to as pellets. More
The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body to achieve promptly, and then maintain, the desired drug concentration for the desired duration of the treatment. That is, the drug delivery system should deliver drug at a rate dictated by the needs of the body over the period of treatment. This idealized objective points to the two aspects most important to drug delivery, namely, spatial placement and temporal delivery of drug. Spatial placement relates to targeting a drug to a specific organ or a tissue, while temporal delivery refers to controlling the rate of drug delivery to the target tissue. An appropriately designed extended release drug delivery system can be a major advance towards solving these two problems. Hence this delivery system has been developed and continues to be the focus of a great deal of attention in both industrial and academic laboratories.
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